I am interested in developing a quantitative understanding of the dynamics of pathogens and immune responses. We use mathematical models and computer simulations to help with the formulation of hypotheses, the design of experiments to test these hypotheses, and the interpretation of experimental data.
Prevention of MTCT of HIV-1 provides an excellent model to identify correlates of protection from infection. We are examining placental antigen presenting cells in HIV-1-exposed and unexposed newborns. The ability of HIV-1 to replicate in these cells will be assessed in a tissue culture model and innate antiviral molecules that limit replication will be defined.
Immunological memory is the capacity of the immune response to remember a previous encounter with an antigen or pathogen such that there is a rapid recall response with re-exposure. Dr. Chandele's research at the New Delhi component of the Emory Vaccine Center is focused on understanding the development of human immunity to infectious diseases with special interest in Dengue and Malaria.
Srilatha Edupuganti is an Infectious Disease physician and a vaccinologist based at the Hope Clinic of Emory Vaccine Center. Vaccine clinical trials for a variety of Infectious Diseases such as HIV, seasonal influenza, avian influenza, etc. and translational human immunology studies are performed the Hope Clinic.
The main focus of Dr. Marconi's research is to identify the biological, social and behavioral conditions which lead to disparities in HIV treatment response for domestic and international populations. Results from these studies inform the design of interventional trials with the goal to improve the quality of life for individuals living with HIV.
My research area is broadly within clinical and translational viral immunology, with my primary research aim to develop predictive immunologic and virologic signatures of risk for viral diseases in patients receiving immunosuppressive agents, and thereby develop treatment modalities to better protect and treat these vulnerable populations.
Dr. Robinson has a multi-protein clade B DNA/MVA vaccine regimen in clinical trials through the US HIV vaccine Trials Network (HVTN). The vaccine was developed in Dr. Robinson's former laboratory at the Emory Vaccine Center in collaboration with Dr. Bernard Moss's laboratory at the US NIH.
Dr Rouphael is currently the Clinical Core Co-PI and director of the Hope Clinic Unit within the NIH funded HIPC U19 ( PI Pulendran). She is the Hope Clinic site director for VTEU ( PI Mulligan ) and co investigator for HVTN and is interested in antimicrobial resistance and translational research on innate immunity, immune senescence and correlates of protection of encapsulated bacteria.
Tianwei Yu is an associate professor of Biostatistics and Bioinformatics. He develops computational methods in systems biology, high-throughput data preprocessing, genomics, and metabolomics. In his collaborative work, he works closely with EVC faculty members on topics such as clinical trial design, high-throughput data analysis, systems biology of vaccine response, HIV immune escape mutations etc.