Vincent C. Marconi, MD
Division of Infectious Diseases, Emory University School of Medicine
The main focus of Dr. Marconi's research is to identify the biological, social and behavioral conditions which lead to disparities in HIV treatment response for domestic and international populations. Results from these studies inform the design of interventional trials with the goal to improve the quality of life for individuals living with HIV.
His domestic research activities have two primary components: (1) immunopathogenesis relevant to inflammation and HIV cure/eradication and (2) improving adherence and retention in care for patients receiving HIV treatment. The immunopathogenesis work includes an effort to elucidate the biological mechanisms associated with immunologic stability for Elite Controllers. Additional observational studies and clinical trials are focused on patients with immunologic non-response, persistent HIV reservoirs and ongoing inflammation while virologically suppressed on antiretroviral treatment (ART). Current research aimed at improving ART adherence and retention in care include assessing the cost-effectiveness of HIV treatment in a free-access healthcare setting and examining the role of various behavioral interventions including a comprehensive, palliative care model, financial incentives, and cognitive-based meditation.
His international research seeks to identify the prevalence of and risk factors for HIV drug resistance after ART. These studies include examining clinical outcomes after subsequent therapy, adherence and pharmacy refill patterns, and the contrast between urban and rural settings. Additional work involves identifying the impact of minority resistance variants on treatment response for patients in South Africa.